General
Screening
Stock library contains >100,000
compounds (2-4 week delivery).
European inventory has >1,000,000
compounds (2-4 months delivery).
Template-Based
Groups with common heterocyclic
lattices.
Targeted
Mechanism based selections. Kinase
Modulators, GPCR Ligands, Anti-infectives,
Potassium Channel Modulators, and
Protease Inhibitors.
Privileged
Structure
Compounds containing chemical motifs
that are more frequently associated
with higher biological activity than
other structures.
Diversity
Compounds pre-selected from available
stock with maximum chemical diversity.
Plant
Extracts
Over 2500
plant extracts in stock and 9,000
available for collection from various
regions. Natural
Products / Natural Product-Derived
Over 4,000 pure substances available
for immediate testing.
Drug-like Characteristics of Compounds
All of our compounds possess drug-like characteristics. LogP,
Molecular weight, number of H-bond donors and acceptors as set forth in
the Lipinski "Rule of Five" can help to determine strong
candidates for drug-like characteristics.
Lipinski rule of five requirements
-
H-bond donors < 5
-
H-bond acceptors < 10
-
Log P < 5
-
Mol. Weight < 500
1 - compounds which satisfy 1 requirement -
1% of all compounds
2 - compounds which satisfy 2
requirements 2% of all compounds
3 - compounds which satisfy 3
requirements 6% of all compounds
4 - compounds which satisfy
all 4 requirements 91% of all compounds
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Compound Libraries