| Reference | Mailhes, J.B., Mastromatteo, C., Fuseler J.W. Transient exposure to the Eg5 kinesin inhibitor monastrol leads to syntelic orientation of chromosomes and aneuploidy in mouse oocytes. Mutation Research. 2004 Apr 11;559(1-2):153-67. Cochran J.C. , Gatial J.E. III, et al. Monastrol Inhibition of the Mitotic Kinesin Eg5. 2005, April 1, J. Biol. Chem., Vol. 280, Issue 13, 12658-12667 Crevel I. M-T. C., Alonso M. C., Cross R. A. Monastrol stabilises an attached low-friction mode of Eg5. Current Biology Magazine. Volume 14, Issue 11, 8 June 2004, Pages R411-R412 Haque. S. A., Hasaka T.P., Brooks A.D., et al. Monastrol, a prototype anti-cancer drug that inhibits a mitotic kinesin, induces rapid bursts of axonal outgrowth from cultured postmitotic neurons. Cell Motility and the Cytoskeleton. Volume 58, Issue 1, Pages 10 - 16 Mayer, T.U., Kapoor, T.M., Haggarty S.J., et al. Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen. Science 29 October 1999: Vol. 286. no. 5441, pp. 971 – 974. Kapoor T.M., Mayera T.U., et al. Probing Spindle Assembly Mechanisms with Monastrol, a Small Molecule Inhibitor of the Mitotic Kinesin, Eg5. The Journal of Cell Biology, Volume 150, Number 5, September 4, 2000 975-988. Yoon S.Y., Choi J.E., Huh J-W., et al. Monastrol, a selective inhibitor of the mitotic kinesin Eg5, induces a distinctive growth profile of dendrites and axons in primary cortical neuron cultures. Cell Motility and the Cytoskeleton, Volume 60, Issue 4 , Pages 181 – 190, Published Online, Wiley-Liss: 4 Mar 2005 Leizerman I., Avunie-Masala R., et al. Differential effects of monastrol in two human cell lines. Cellular and Molecular Life Sciences. Vol. 61, Number 16 / August, 2004, 2060-2070. Luo, L., Carson, J., et al. Mechanism of Inhibition of Human KSP by Monastrol: Insights from Kinetic Analysis and the Effect of Ionic Strength on KSP Inhibition. Biochemistry, 43 (48), 15258 -15266, 2004. Maliga Z., Xing, J., et al. A Pathway of Structural Changes Produced by Monastrol Binding to Eg5. J. Biol. Chem., Vol. 281, Issue 12, 7977-7982, March 24, 2006. Marcus, A., Peters U., Thomas S., et al. Mitotic Kinesin Inhibitors Induce Mitotic Arrest and Cell Death in Taxol-resistant and -sensitive Cancer Cells. J. Biol. Chem., Vol. 280, Issue 12, 11569-11577, March 25, 2005. |
