NDL-3000 elaborates on structural variety of pure natural compounds and includes synthetic compounds and synthetically modified pure natural compounds: alkaloids, natural phenols, nucleoside analogs, carbohydrates, purines, pyrimidines, flavonoids, steroidal compounds, and natural amino acids. This list is incomplete.
NDL-3000 is a “natural” extension of the well-known NPL-640, Pure Natural Product Library, in design and structural diversity.
Compounds comply with screening purity standards. NDL-3000 is available as a collection of either 3,000 compounds, individual compounds, or smaller subsets. Custom formatting is available in vials or 96/384 plates.
For structural data and pricing please contact us
Natural Products in Journal of Medicinal Chemistry (JMC)
One of the latest Miniperspectives Journal of Medicinal Chemistry examines the benefit of pairing natural products chemistry and synthetic organic chemistry: "A combination of natural products chemistry and focused library synthesis furnishes a powerful tool for drug discovery."
Ojuma, I. Modern Natural Products Chemistry and Drug Discovery. J.Med.Chem. 2008, 51, 9, 2587-2588.
The paramount importance of nature-sourced and nature-inspired products in drug discovery is proverbial. Statistics keeps exploring and screening natural products and their derivatives topical: combinatorial chemistry produced only one FDA-approved drug for the last 20 years compared to 57.7% of approvals for natural-products-based drugs.
At the same time evolution in combinatorial chemistry, parallel synthesis, computational chemistry, and molecular target-based drug discovery accumulated valuable methods and tools that can be applied to natural material.
Another study investigates paring natural products chemistry and synthetic organic chemistry in more detail, following successful drug discovery examples in pharmaceutical industry:
Newman, D. J. Natural products as leads to potential drugs: an old process or the new hope for drug discovery? J.Med.Chem. 2008, 51, 9, 2587-2588.
Following discovery trends, TimTec NDL-3,000, Natural Products Derivatives Library of 3,000 compounds, is a cross-over between pure nature molecules and synthetic organic chemistry. NDL-3000 elaborates on structural diversity of pure natural compounds including natural derivatives, analogs, semi-natural compounds, and mimics.
